The cytoskeleton is an essential element of a eukaryotic cell which informs both form and function and ultimately has physiological consequences for the organism. In addition compound Aloin, an Aloe exudate showed potent Mtb-FtsZ inhibition (IC 50 = 16.7 ± 0.4 μM)but exhibited poor anti-mycobacterial activity (>500 μM). Further these molecules also altered the FtsZ gene expression by 3-fold when compared to untreated.

They appear to be bacteriostatic, as well as treatment with these compounds led to a 3× increase in cell length of M. The results revealed Piperine (IC 50 = 21.2 ± 0.7 μM), 4-Bromo di-methoxy coumarin (IC 50 = 13.0 ± 1.6 μM)and Di-ethyl amino methyl coumarin (IC 50 = 19.4 ± 1.1)as potent Mtb-FtsZ GTPase inhibitors which showed considerable antibacterial activity (84.0 ± 2.6 μM, 56.0 ± 4.3 μM and 108 ± 7.1 μM respectively)against M. This study employs the use of pharmacophore models derived from two different datasets based on Mtb-FtsZ GTPase inhibition and whole cell antibacterial activity, to virtually screen and shortlist novel compounds from In-house small molecule library as Mtb-FtsZ inhibitors and evaluate their in-vitro and ex-vivo activity. FtsZ is a GTP hydrolyzing protein, conserved in prokaryotes that plays a central role in Z-ring formation during cell division cytokinesis stage. Tuberculosis, caused by Mycobacterium tuberculosis has been one of the primal afflictions to human, and owing to the current scenario of drug resistance, newer drugs, and alternate targets are required to mitigate the disease. *** Take out the divider line between content and sidebar ***/ * Content Template: template-for-events - start */ Curated by Monica Scardecchia.įor further Tel.

The Instagram account in_cesso_veritas will simultaneously project pictures of toilets found around the world by his IG audience.Ĭaterina Borruso, Silvia Capiluppi, Carmine Caputo di Roccanova, Margherita Cavallo, DaDiL, Li Ding, Nazanin Farahbod, Fernanda Fedi, Gretel Fehr, Fabio Fondacci, Elmar Giacummo, Vito Giacummo, Francesco Lasalandra, Elisa Mivar Marchesani, Edy Persichelli, Antonella Prota-Giurleo, Roberto Ramirez, Claudia Rios, Etta Rossi, Serena Rossi, Studio Pace10, topylabrys, Micaela Tornaghi, Yuko Tsukamoto, Franco Vertovez.Ĭonceived and created by Ornella Piluso (topylabrys), the Artistic Director of Arte da mangiare mangiare Arte. It’s a symbol for the comfort and intimacy we find in bathrooms. Toilets are a human right an economic and productive investment: they can limit social spending and increase education improve the quality of life and are fundamental for a good health.įor its exhibition Arte da mangiare chose to represent books, toilet books, as they’re an essential element. It’s a fight against poverty and undernourishment, but it’s also a war on pollution since non treated wastewaters are released into rivers, lakes and oceans. One in three doesn’t have adequate sanitation which obstructs a secure waste disposal, doesn’t have proper hygiene, nor clean water, causing an increment of the transmission of diseases, and subsequently the death of 280 thousand people every year. It’s an official United Nation International observance day, established in 2013 in order to inspire action to tackle the global sanitation crisis. The Cultural Association Arte da mangiare mangiare Arte and MAF – Museo Acqua Franca present the exhibition “Toilet Book”, organized for the World Toilet Day which occurs in November 19. Opening on Tuesday the 19 th of November 2019 – 18:00h The exhibition will last until Monday the 2 nd of December 2019 according to scheduled times Centrale dell’Acqua, Piazza Diocleziano 5, Milano

Antonella prota giurleo